Combined Therapy with Idebenone and Deferiprone in Patients with Friedreich’s Ataxia

@article{VelascoSnchez2010CombinedTW,
  title={Combined Therapy with Idebenone and Deferiprone in Patients with Friedreich’s Ataxia},
  author={Daniel Velasco-S{\'a}nchez and Asunci{\'o}n Aracil and R. Alejandra Montero and Ana Mas and Lorenzo Jim{\'e}nez and M. Mar O’Callaghan and Mar{\'i}a Laura Tondo and Antoni Capdevila and Josep Blanch and Rafael Artuch and Merc{\'e}des Pineda},
  journal={The Cerebellum},
  year={2010},
  volume={10},
  pages={1-8}
}
Iron chelators are a new therapeutical approach for patients with Friedreich’s ataxia, on the basis that oxidative cell damage that occurs in these patients is due to the increasing deposits of mitochondrial iron pools. The objective of the study was to evaluate the effects of the combined therapy of idebenone and low oral doses of deferiprone on the neurological signs and cardiac function parameters. This study was designed as a prospective open-label single-arm study. Twenty Friedreich’s… CONTINUE READING

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Emerging therapies in Friedreich's ataxia.

Neurodegenerative disease management • 2016

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