Combined TLR and CD40 Triggering Induces Potent CD8+ T Cell Expansion with Variable Dependence on Type I IFN

@article{Ahonen2004CombinedTA,
  title={Combined TLR and CD40 Triggering Induces Potent CD8+ T Cell Expansion with Variable Dependence on Type I IFN},
  author={Cory L. Ahonen and Christie L. Doxsee and Sean M. Mcgurran and Tony R. Riter and William F. Wade and Richard J. Barth and John P. Vasilakos and Randolph J. Noelle and Ross M Kedl},
  journal={The Journal of Experimental Medicine},
  year={2004},
  volume={199},
  pages={775 - 784}
}
Toll-like receptors are important in the activation of innate immunity, and CD40 is a molecule critical for many T and B cell responses. Whereas agonists for either pathway have been used as vaccine adjuvants, we show that a combination of Toll-like receptor (TLR)7 and CD40 agonists synergize to stimulate CD8+ T cell responses 10-20-fold greater than the use of either agonist alone. Antigen-specific CD8+ T cells elicited from combination CD40/TLR7 treatment demonstrated both lytic activities… CONTINUE READING

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