Combined Nicotinic and Muscarinic Blockade in Elderly Normal Volunteers: Cognitive, Behavioral, and Physiologic Responses

@article{Little1998CombinedNA,
  title={Combined Nicotinic and Muscarinic Blockade in Elderly Normal Volunteers: Cognitive, Behavioral, and Physiologic Responses},
  author={John T Little and Douglas N Johnson and Marcia Minichiello and Herb Weingartner and Trey P Sunderland},
  journal={Neuropsychopharmacology},
  year={1998},
  volume={19},
  pages={60-69}
}
Establishing a pharmacologic model of the memory deficits of Alzheimer's disease could be an important tool in understanding how memory fails. We examined the combined effects of the muscarinic antagonist scopolamine and the nicotinic antagonist mecamylamine in eight normal elderly volunteers (age 61.9 ± 8.3 yrs, SD). Each received four separate drug challenges (scopolamine (0.4 mg IV), mecamylamine (0.2 mg/kg up to 15 mg PO), mecamylamine + scopolamine, and placebo). There was a trend toward… CONTINUE READING
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Mental status examination for organic mental syndrome in the elderly patient

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