Combined Metabolomics and Transcriptomics Approaches to Assess the IL-6 Blockade as a Therapeutic of ALS: Deleterious Alteration of Lipid Metabolism

@article{Patin2016CombinedMA,
  title={Combined Metabolomics and Transcriptomics Approaches to Assess the IL-6 Blockade as a Therapeutic of ALS: Deleterious Alteration of Lipid Metabolism},
  author={Franck Patin and Thomas Baranek and Patrick Vourc’h and L. Nadal-Desbarats and J. J. M. Goossens and Sylviane Marouillat and A F Dessein and Amandine Descat and Blandine Madji Hounoum and Cl{\'e}ment Bruno and Herv{\'e} Watier and Mustafa Si-Tahar and Samuel Leman and Jean-Claude Lecron and C. R. Andres and Philippe Corcia and H{\'e}l{\`e}ne Blasco},
  journal={Neurotherapeutics},
  year={2016},
  volume={13},
  pages={905-917}
}
In amyotrophic lateral sclerosis (ALS), motor neuron degeneration occurs simultaneously with systemic metabolic impairment and neuroinflammation. Playing an important role in the regulation of both phenomena, interleukin (IL)-6, a major cytokine of the inflammatory response has been proposed as a target for management of ALS. Although a pilot clinical trial provided promising results in humans, another recent preclinical study showed that knocking out the IL-6 gene in mice carrying ALS did not… CONTINUE READING
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