Combined Effects of Thrombosis Pathway Gene Variants Predict Cardiovascular Events

@article{Auro2007CombinedEO,
  title={Combined Effects of Thrombosis Pathway Gene Variants Predict Cardiovascular Events},
  author={Kirsi Auro and Mervi Alanne and Kati Kristiansson and Kaisa Silander and Kari A Kuulasmaa and Veikko V Salomaa and L. Peltonen and Markus Perola},
  journal={PLoS Genetics},
  year={2007},
  volume={3},
  pages={377 - 388}
}
The genetic background of complex diseases is proposed to consist of several low-penetrance risk loci. Addressing this complexity likely requires both large sample size and simultaneous analysis of different predisposing variants. We investigated the role of four thrombosis genes: coagulation factor V (F5), intercellular adhesion molecule 1 (ICAM1), protein C (PROC), and thrombomodulin (THBD) in cardiovascular diseases. Single allelic gene variants and their pair-wise combinations were analyzed… CONTINUE READING

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