Combined Effects of Simulated Microgravity and Radiation Exposure on Osteoclast Cell Fusion

  title={Combined Effects of Simulated Microgravity and Radiation Exposure on Osteoclast Cell Fusion},
  author={S. Shanmugarajan and Ye Zhang and M. Moreno‐Villanueva and Ryan Clanton and L. Rohde and G. Ramesh and J. Sibonga and Honglu Wu},
  journal={International Journal of Molecular Sciences},
The loss of bone mass and alteration in bone physiology during space flight are one of the major health risks for astronauts. Although the lack of weight bearing in microgravity is considered a risk factor for bone loss and possible osteoporosis, organisms living in space are also exposed to cosmic radiation and other environmental stress factors. As such, it is still unclear as to whether and by how much radiation exposure contributes to bone loss during space travel, and whether the effects… Expand
The Influence of Radiation on Bone and Bone Cells—Differential Effects on Osteoclasts and Osteoblasts
Gene Expression in Osteoblasts and Osteoclasts Under Microgravity Conditions: A Systematic Review
The individual and combined effects of spaceflight radiation and microgravity on biologic systems and functional outcomes
  • J. Willey, R. Britten, +7 authors X. Mao
  • Medicine
  • Journal of environmental science and health. Part C, Toxicology and carcinogenesis
  • 2021
4-Acetylantroquinonol B Inhibits Osteoclastogenesis by Inhibiting the Autophagy Pathway in a Simulated Microgravity Model
Transcriptional Homeostasis of Oxidative Stress-Related Pathways in Altered Gravity
Osteoclast Multinucleation: Review of Current Literature


Space Radiation and Bone Loss.
Acute exposure to high dose γ-radiation results in transient activation of bone lining cells.
Oxidative stress and gamma radiation-induced cancellous bone loss with musculoskeletal disuse.
Ionizing Radiation and Bone Loss: Space Exploration and Clinical Therapy Applications
A murine model for bone loss from therapeutic and space-relevant sources of radiation.
Differences in responses to X-ray exposure between osteoclast and osteoblast cells
Microgravity promotes osteoclast activity in medaka fish reared at the international space station