Combined Effects of Botulinum Toxin Injection and Hind Limb Unloading on Bone and Muscle

@article{Ellman2013CombinedEO,
  title={Combined Effects of Botulinum Toxin Injection and Hind Limb Unloading on Bone and Muscle},
  author={Rachel Ellman and Daniel J. Grasso and Miranda van Vliet and Daniel J. Brooks and Jordan Matthew Spatz and Christine Conlon and Mary L Bouxsein},
  journal={Calcified Tissue International},
  year={2013},
  volume={94},
  pages={327-337}
}
Bone receives mechanical stimulation from two primary sources, muscle contractions and external gravitational loading; but the relative contribution of each source to skeletal health is not fully understood. Understanding the most effective loading for maintaining bone health has important clinical implications for prescribing physical activity for the treatment or prevention of osteoporosis. Therefore, we investigated the relative effects of muscle paralysis and reduced gravitational loading… CONTINUE READING

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