Combined Deletion of Macrophage ABCA1 and ABCG1 Leads to Massive Lipid Accumulation in Tissue Macrophages and Distinct Atherosclerosis at Relatively Low Plasma Cholesterol Levels

@article{Out2008CombinedDO,
  title={Combined Deletion of Macrophage ABCA1 and ABCG1 Leads to Massive Lipid Accumulation in Tissue Macrophages and Distinct Atherosclerosis at Relatively Low Plasma Cholesterol Levels},
  author={Ruud Out and Menno Hoekstra and Kim L. L. Habets and Illiana Meurs and Vivian de Waard and Reeni B. Hildebrand and Yanan Wang and Giovanna Chimini and Johan Kuiper and Th J C van Berkel and Miranda van Eck},
  journal={Arteriosclerosis, Thrombosis, and Vascular Biology},
  year={2008},
  volume={28},
  pages={258-264}
}
Objective—The purpose of this study was to evaluate the effect of the combined deletion of ABCA1 and ABCG1 expression in macrophages on foam cell formation and atherosclerosis. Methods and Results—LDL receptor knockout (KO) mice were transplanted with bone marrow from ABCA1/ABCG1 double KO (dKO) mice. Plasma cholesterol levels after 6 weeks of Western-type diet (WTD) feeding were significantly lower in dKO transplanted mice than ABCA1 KO, ABCG1 KO, and control transplanted animals. Extreme foam… Expand
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