Combined DNA vaccines formulated in DDA enhance protective immunity against tuberculosis.

@article{Cai2004CombinedDV,
  title={Combined DNA vaccines formulated in DDA enhance protective immunity against tuberculosis.},
  author={Hao Cai and Xia Tian and Xiao- Dong Hu and Y. H. Zhuang and Ying Xiao Zhu},
  journal={DNA and cell biology},
  year={2004},
  volume={23 7},
  pages={450-6}
}
This study evaluated the adjuvant Dimethyldioctyldecyl Ammonium Bromide (DDA) effect on the protective immunity induced by a combination of plasmids containing genes encoding antigens Ag85B, MPT-83, and ESAT-6 from Mycobacterium tuberculosis. The combined DNA vaccines in DDA resulted in significant increases in both specific IgG and splenic T-cell-derived Th1-type cytokine gamma interferon (IFN-gamma) production in response to the three purified antigens when compared to that of combined DNA… CONTINUE READING