Combined Cancer Immunotherapy Against Aurora Kinase A.

Abstract

Aurora kinase A (AURKA) is a centrosomal protein that is overexpressed in a number of human malignancies and can contribute to tumor progression. As we used this protein as a target of DNA immunization, we increased its immunogenicity by the addition of the PADRE helper epitope and decreased its potential oncogenicity by mutagenesis of the kinase domain… (More)
DOI: 10.1097/CJI.0000000000000120

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