Combined Blockade of Cholinergic Receptors Shifts the Brain from Stimulus Encoding to Memory Consolidation

@article{Rasch2006CombinedBO,
  title={Combined Blockade of Cholinergic Receptors Shifts the Brain from Stimulus Encoding to Memory Consolidation},
  author={Bj{\"o}rn Rasch and Jan Born and Steffen Gais},
  journal={Journal of Cognitive Neuroscience},
  year={2006},
  volume={18},
  pages={793-802}
}
  • B. Rasch, J. Born, S. Gais
  • Published 1 May 2006
  • Computer Science, Medicine, Psychology
  • Journal of Cognitive Neuroscience
High central nervous system levels of acetylcholine (ACh) are commonly regarded as crucial for learning and memory, and a decline in cholinergic neurotransmission is associated with Alzheimer's dementia. However, recent findings revealed exceptions to this rule: The low ACh tone characterizing slowwave sleep (SWS) has proven necessary for consolidation of hippocampus-dependent declarative memories during this sleep stage. Such observations, together with recent models of a hippocampal… Expand
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