Combined Anti-Inflammatory and Anti-AGE Drug Treatments have a Protective Effect on Intervertebral Discs in Mice with Type 1 Diabetes

  • Published 2011

Abstract

INTRODUCTION: Diabetes mellitus type 1 is a systemic disease affecting many organs [1]. Diabetes is an etiologic factor in spinal stenosis, intervertebral disc (IVD) degeneration, and vertebral pathology [2] and these relationships may be associated with increased levels of inflammation and accumulation of advanced glycation end-products (AGEs) [3]. This study determined the effects of type 1 diabetes on vertebral and IVD morphology and evaluated if anti-inflammatory and AGE inhibition drugs could mitigate such effects. METHODS:Treatment & control mice were maintained for 6.5 months (21 mice,n=6-8 per group). In diabetic animals (DB), kidney disease was induced in 4-8 week old ROP Os/+ mice with 2 weeks of streptozotocin injections, diabetes development was then monitored for 1 month by blood glucose levels (> 200 mg/dl), and animals were maintained another 5 months. Treated (En+Pyr+PPS) ROP Os/+ animals underwent the same diabetes induction protocol but were given 5 months of treatments including: Enalapril (EN, antihypertensive drug commonly used in diabetic patients); Pyridoxamine (PYR, an AGE inhibitor), and Pentosan Polysulphate (PPS, a broad acting anti-inflammatory). Non diabetic ROP Os/+ mice(Control) were also maintained. (Fig.1)

Cite this paper

@inproceedings{2011CombinedAA, title={Combined Anti-Inflammatory and Anti-AGE Drug Treatments have a Protective Effect on Intervertebral Discs in Mice with Type 1 Diabetes}, author={}, year={2011} }