Combined Anti-Angiogenic Therapy Targeting PDGF and VEGF Receptors Lowers the Interstitial Fluid Pressure in a Murine Experimental Carcinoma

@inproceedings{KosowskaWardga2009CombinedAT,
  title={Combined Anti-Angiogenic Therapy Targeting PDGF and VEGF Receptors Lowers the Interstitial Fluid Pressure in a Murine Experimental Carcinoma},
  author={Agnieszka Kłosowska-Wardęga and Yoko Hasumi and Mikhail Burmakin and Aive {\AA}hgren and Linda Elin Birkhaug Stuhr and Ingrid Johanne Moen and R. K. Reed and Kristofer Rubin and Carina Hellberg and C M Heldin},
  booktitle={PloS one},
  year={2009}
}
Elevation of the interstitial fluid pressure (IFP) of carcinoma is an obstacle in treatment of tumors by chemotherapy and correlates with poor drug uptake. Previous studies have shown that treatment with inhibitors of platelet-derived growth factor (PDGF) or vascular endothelial growth factor (VEGF) signaling lowers the IFP of tumors and improve chemotherapy. In this study, we investigated whether the combination of PDGFR and VEGFR inhibitors could further reduce the IFP of KAT-4 human… CONTINUE READING

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