Combined Action of Doxorubicin and Gestagens on Doxorubicin-Sensitive and Doxorubicin-Resistant MCF-7 Cells

@article{Sergeev2004CombinedAO,
  title={Combined Action of Doxorubicin and Gestagens on Doxorubicin-Sensitive and Doxorubicin-Resistant MCF-7 Cells},
  author={P. V. Sergeev and A. V. Semeikin and T. A. Fedotcheva and R. V. Samoilikov and A. V. Kamernitskii and Inna S. Levina and Vladimir M. Rzheznikov and Galina S. Grinenko and Yu. N. Korystov and Natalia V Ermakova and Vera V. Shaposhnikova and N. L. Shimanovskii},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2004},
  volume={136},
  pages={460-463}
}
The combined cytostatic effect of doxorubicin and gestagens progesterone, medroxyprogesterone acetate, mecigestone, and butagest on doxorubicin-resistant and doxorubicin-sensitive human breast cancer MCF-7 cells was studied by the MTT assay. On the 6th day of incubation progesterone, medroxyprogesterone acetate, mecigestone, and butagest in high concentrations (10-5 M) potentiated the cytostatic action of doxorubicin in sensitive and resistant cells by 30-50%. Potentiation of the cytostatic… Expand
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