Combined 3D-QSAR modeling and molecular docking study on multi-acting quinazoline derivatives as HER2 kinase inhibitors

@inproceedings{Mirzaie2013Combined3M,
  title={Combined 3D-QSAR modeling and molecular docking study on multi-acting quinazoline derivatives as HER2 kinase inhibitors},
  author={Sako Mirzaie and M. Monajjemi and Mohammad Saeed Hakhamaneshi and Fardin Fathi and Mostafa Jamalan},
  booktitle={EXCLI journal},
  year={2013}
}
A series of new quinazoline derivatives has been recently reported as potent multi-acting histone deacetylase (HDAC), epidermal growth factor receptor (EGFR), and human epidermal growth factor receptor 2 (HER2) inhibitors. HER2 is one of the major targets for the treatment of breast cancer and other carcinomas. Three-dimensional structure-activity relationship (3D-QSAR) is a well-known technique, which is used to drug design and development. This technique is used for quantitatively predicting… CONTINUE READING

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