Combined 1p/19q loss in oligodendroglial tumors: predictive or prognostic biomarker?

  title={Combined 1p/19q loss in oligodendroglial tumors: predictive or prognostic biomarker?},
  author={Michael Weller and Hilmar Berger and Christian Hartmann and Johannes Schramm and Manfred Westphal and Miranda Simon and Roland Goldbrunner and Dietmar Krex and Joachim Peter Steinbach and Christoph B. Ostertag and Markus L{\"o}ffler and Torsten Pietsch and Andreas von Deimling},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={13 23},
PURPOSE The combined loss of genetic material on chromosomes 1p and 19q is strongly associated with favorable outcome in patients with WHO grade 3 anaplastic oligodendroglial tumors. The prognostic value of 1p/19q loss in WHO grade 2 oligodendroglial tumors is less well defined. Importantly, the possible effect of combined 1p/19q loss has not been studied in patients who were not treated with radiotherapy or chemotherapy. EXPERIMENTAL DESIGN Seventy-six patients with oligodendroglioma (n = 33… CONTINUE READING


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