Combined ω3 and ω6 Supplementation in Children With Attention-Deficit Hyperactivity Disorder (ADHD) Refractory to Methylphenidate Treatment

@article{Perera2012CombinedA,
  title={Combined $\omega$3 and $\omega$6 Supplementation in Children With Attention-Deficit Hyperactivity Disorder (ADHD) Refractory to Methylphenidate Treatment},
  author={Hemamali Perera and Kamal Chandima Jeewandara and Sudarshi Seneviratne and Chandima Guruge},
  journal={Journal of Child Neurology},
  year={2012},
  volume={27},
  pages={747 - 753}
}
Children (6-12 years) with attention-deficit hyperactivity disorder (ADHD) being treated with methylphenidate and standard behavior therapy for more than 6 months, whose parents reported no improvement in behavior and academic learning, were randomly assigned to receive supplementation with a combined ω3 and ω6 preparation or a placebo. Outcome was measured at 3 and 6 months after treatment using a self-assessment checklist completed by the parents. Statistically significant improvement was… 

Figures and Tables from this paper

Effect of omega-3 plus methylphenidate as an alternative therapy to reduce attention deficit-hyperactivity disorder in children
TLDR
It is demonstrated that a specific dose of omega-3 for 8 weeks had no effect on ADHD, and the results showed no statistically significant difference between the methylphenidate with Omega-3 group and methyl phenidate with placebo group based on the Parents ADHD Rating Scale.
Tocotrienol-rich fractions (TRF) supplementation in school-going children with Attention Deficit/Hyperactive Disorder (ADHD): a randomized controlled trial
TLDR
TRF was not more effective than placebo in reducing the ADHD symptoms as measured by the VAPRS and VATRS, and future studies should consider using an objective outcome measurement as well as earlier age of supplementation.
Do Omega-3/6 Fatty Acids Have a Therapeutic Role in Children and Young People with ADHD?
TLDR
Given disparaging feelings towards psychostimulant medications, omega-3/6 fatty acids offer great promise as a suitable adjunctive therapy for ADHD.
Non-stimulant interventions in ADHD
TLDR
In study 4 CPS showed promise in reducing problem behaviours in children with ADHD and ODD, and children with severe ADHD symptoms may be improved by combining CPS and ADHD medication.
Omega-3 Polyunsaturated Fatty Acids in Youths with Attention Deficit Hyperactivity Disorder (ADHD): A Systematic Review and Meta-analysis of Clinical Trials and Biological Studies
TLDR
There is evidence that n-3 PUFAs supplementation monotherapy improves clinical symptoms and cognitive performances in children and adolescents with ADHD, and that these youth have a deficiency in n- 3 PUFas levels.
Review on the Efficacy of Omega-3 in the Treatment of Attention-Deficit Hyperactivity Disorder
TLDR
Evidence that PUFAs supplementa-tion provides benefits for ADHD was yet limited, with mixed results due to selection variability criteria, variability of supple-mentation, and short follow-up intervals.
Attention Deficit Hyperactivity Disorder and Omega-3 Fatty Acid Supplementation: A Systematic Review
TLDR
Beneficial effects of omega-3 fatty acids in ADHD treatment are concluded while it is important to emphasize the need for additional and more comprehensive clinical trials about this issue.
Use of Non-Pharmacological Supplementations in Children and Adolescents with Attention Deficit/Hyperactivity Disorder: A Critical Review
TLDR
No clear effect on single cognitive, affective, or behavioral domain was found for any supplementation category, and findings should represent evidence for the efficacy of dietary supplementation as a support to standard pharmacological and psychological therapies in children and adolescents with ADHD.
Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents - assessment of adverse events in non-randomised studies.
TLDR
A systematic review of randomised clinical trials (RCTs) for methylphenidate treatment for children and adolescents with ADHD demonstrated no increase in serious adverse events, but a high proportion of participants suffered a range of non-serious adverse events.
...
...

References

SHOWING 1-10 OF 34 REFERENCES
Symptomatic improvement in children with ADHD treated with long-term methylphenidate and multimodal psychosocial treatment.
TLDR
In stimulant-responsive children with ADHD, there is no support for adding ambitious long-term psychosocial intervention to improve ADHD and oppositional defiant disorder symptoms.
EFA supplementation in children with inattention, hyperactivity, and other disruptive behaviors
TLDR
The results of this pilot study suggest the need for further research with both n−3 FA and vitamin E in children with behavioral disorders.
Omega-3/Omega-6 Fatty Acids for Attention Deficit Hyperactivity Disorder
TLDR
A subgroup of children and adolescents with ADHD, characterized by inattention and associated neurodevelopmental disorders, treated with omega 3/6 fatty acids for 6 months responded with meaningful reduction of ADHD symptoms.
A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. The MTA Cooperative Group. Multimodal Treatment Study of Children with ADHD.
TLDR
The authors' carefully crafted medication management was superior to behavioral treatment and to routine community care that included medication for ADHD symptoms, and may have provided modest advantages for non-ADHD symptom and positive functioning outcomes.
The Oxford-Durham Study: A Randomized, Controlled Trial of Dietary Supplementation With Fatty Acids in Children With Developmental Coordination Disorder
TLDR
Fatty acid supplementation may offer a safe efficacious treatment option for educational and behavioral problems among children with DCD, and an inability to detect any improvement in motor skills reflects the measures used.
Risperidone effects in the presence/absence of psychostimulant medicine in children with ADHD, other disruptive behavior disorders, and subaverage IQ.
TLDR
Risperidone was a safe and effective treatment, with or without a combined psychostimulant, for both disruptive behavior disorders and comorbid ADHD in children.
Assessment of outcome of an ADHD treatment program using parent feedback
TLDR
Close involvement of parents in monitoring outcome of treatment of ADHD helps to focus on aspects of care relevant to them.
The Impact of Polyunsaturated Fatty Acids in Reducing Child Attention Deficit and Hyperactivity Disorders
TLDR
Evidence is too limited to reach definitive conclusions but suggests that research on the impact of long-chain PUFA (n-3 and n-6) should continue with special focus on individual differences (genetic and fatty acid markers), mechanisms, mechanisms, and new enhanced methods of systematic observations of behaviors.
[Omega-3 and omega-6 fatty acids in the treatment of children and adolescents with ADHD].
TLDR
There are indications that there is a theoretical rationale for the effectiveness of fatty acids in the treatment of adhd, however, treatment with omega-3 and omega-6 fatty acids is not recommended because it does not qualify as being evidence-based.
...
...