Combinatorial use of antibodies to secreted mycobacterial proteins in a host immune system-independent test for tuberculosis.

@article{Landowski2001CombinatorialUO,
  title={Combinatorial use of antibodies to secreted mycobacterial proteins in a host immune system-independent test for tuberculosis.},
  author={C P Landowski and Henry P Godfrey and S I Bentley-Hibbert and Xuemin Liu and Zhi-Cheng Huang and Ricardo Garc{\'i}a Sep{\'u}lveda and Kris Huygen and Maria Laura Gennaro and Fred H. Moy and Scott A. Lesley and Mary Haak-Frendscho},
  journal={Journal of clinical microbiology},
  year={2001},
  volume={39 7},
  pages={2418-24}
}
Laboratory diagnosis of tuberculosis is often difficult. Immunodetection of circulating Mycobacterium tuberculosis proteins shed during active infection would not depend on an intact host immune response and could take advantage of the speed and low costs afforded by antibody-based assays. We previously showed that patients with active tuberculosis had increased levels of circulating antigen 85 (Ag85) proteins independent of their tuberculin skin test status (S. I. Bentley-Hibbert, X. Quan, T… CONTINUE READING

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