Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models

@inproceedings{Issa2012CombinatorialTO,
  title={Combinatorial targeting of FGF and ErbB receptors blocks growth and metastatic spread of breast cancer models},
  author={Amine Issa and Jason W Gill and Marinus R. Heideman and Ozgur D. Sahin and Stefan Wiemann and Julien H. Dey and Nancy E. Hynes},
  booktitle={Breast Cancer Research},
  year={2012}
}
Targeting receptor tyrosine kinases (RTKs) with kinase inhibitors is a clinically validated anti-cancer approach. However, blocking one signaling pathway is often not sufficient to cause tumor regression and the effectiveness of individual inhibitors is often short-lived. As alterations in fibroblast growth factor receptor (FGFR) activity have been implicated in breast cancer, we examined in breast cancer models with autocrine FGFR activity the impact of targeting FGFRs in vivo with a selective… CONTINUE READING
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