Combinatorial synthesis through disulfide exchange: discovery of potent psammaplin A type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA).

@article{Nicolaou2001CombinatorialST,
  title={Combinatorial synthesis through disulfide exchange: discovery of potent psammaplin A type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA).},
  author={Kyriacos C Nicolaou and Robert M Hughes and Jeffery A Pfefferkorn and Sof{\'i}a Barluenga and Anthony J. Roecker},
  journal={Chemistry},
  year={2001},
  volume={7 19},
  pages={
          4280-95
        }
}
Psammaplin A is a symmetrical bromotyrosine-derived disulfide natural product isolated from the Psammaplysilla sponge, which exhibits in vitro antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). Inspired by the structure of this marine natural product, a combinatorial scrambling strategy for the construction of heterodimeric disulfide analogues was developed and applied to the construction of a 3828-membered library starting from 88 homodimeric disulfides. These… CONTINUE READING
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