Combinatorial signals from the neural tube, floor plate and notochord induce myogenic bHLH gene expression in the somite.

@article{Mnsterberg1995CombinatorialSF,
  title={Combinatorial signals from the neural tube, floor plate and notochord induce myogenic bHLH gene expression in the somite.},
  author={Andrea M{\"u}nsterberg and Andrew B. Lassar},
  journal={Development},
  year={1995},
  volume={121 3},
  pages={651-60}
}
The neural tube, floor plate and notochord are axial tissues in the vertebrate embryo which have been demonstrated to play a role in somite morphogenesis. Using in vitro coculture of tissue explants, we have monitored inductive interactions of these axial tissues with the adjacent somitic mesoderm in chick embryos. We have found that signals from the neural tube and floor plate/notochord are necessary for expression of the myogenic bHLH regulators MyoD, Myf5 and myogenin in the somite… CONTINUE READING

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