Combinatorial signals by inflammatory cytokines and chemokines mediate leukocyte interactions with extracellular matrix.

@article{Vaday2001CombinatorialSB,
  title={Combinatorial signals by inflammatory cytokines and chemokines mediate leukocyte interactions with extracellular matrix.},
  author={Gayle G. Vaday and Suzanne Franitza and Hagai Schor and Iris Hecht and Alexander Brill and Liora Cahalon and Rami Hershkoviz and Ofer Lider},
  journal={Journal of leukocyte biology},
  year={2001},
  volume={69 6},
  pages={885-92}
}
On their extravasation from the vascular system into inflamed tissues, leukocytes must maneuver through a complex insoluble network of molecules termed the extracellular matrix (ECM). Leukocytes navigate toward their target sites by adhering to ECM glycoproteins and secreting degradative enzymes, while constantly orienting themselves in response to specific signals in their surroundings. Cytokines and chemokines are key biological mediators that provide such signals for cell navigation… CONTINUE READING
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TNF-a associated with extracellular matrix fibronectin provides a stop signal for chemotactically migrating T cells

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TGF-b suppresses TNF-a-induced matrix metalloproteinase-9 (MMP-9) expression in monocytes

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