Combinatorial signaling in the heart orchestrates cardiac induction, lineage specification and chamber formation.

@article{Dunwoodie2007CombinatorialSI,
  title={Combinatorial signaling in the heart orchestrates cardiac induction, lineage specification and chamber formation.},
  author={Sally L. Dunwoodie},
  journal={Seminars in cell & developmental biology},
  year={2007},
  volume={18 1},
  pages={
          54-66
        }
}
The complexity of mammalian cardiogenesis is compounded, as the heart must function in the embryo whilst it is still being formed. Great advances have been made recently as additional cardiac progenitor cell populations have been identified. The induction and maintenance of these progenitors, and their deployment to the developing heart relies on combinatorial molecular signalling, a feature also of cardiac chamber formation. Many forms of congenital heart disease in humans are likely to arise… CONTINUE READING
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