Combinatorial screening of cell proliferation on poly(L-lactic acid)/poly(D,L-lactic acid) blends.

@article{Simon2005CombinatorialSO,
  title={Combinatorial screening of cell proliferation on poly(L-lactic acid)/poly(D,L-lactic acid) blends.},
  author={Carl G. Simon and Naomi Eidelman and Scott B. Kennedy and Amit Sehgal and Chetan A Khatri and Newell Washburn},
  journal={Biomaterials},
  year={2005},
  volume={26 34},
  pages={6906-15}
}
We have combined automated fluorescence microscopy with a combinatorial approach for creating polymer blend gradients to yield a rapid screening method for characterizing cell proliferation on polymer blends. A gradient in polymer blend composition of poly(L-lactic acid) (PLLA) and poly(D,L-lactic acid) (PDLLA) was created in the form of a strip-shaped film and was annealed to allow PLLA to crystallize. Fourier transform infrared (FTIR) microspectroscopy was used to determine the composition in… CONTINUE READING

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