Combinatorial roles for BMPs and Endothelin 1 in patterning the dorsal-ventral axis of the craniofacial skeleton.

@article{Alexander2011CombinatorialRF,
  title={Combinatorial roles for BMPs and Endothelin 1 in patterning the dorsal-ventral axis of the craniofacial skeleton.},
  author={Courtney M. Alexander and Elizabeth Zuniga and Ira L. Blitz and Naoyuki Wada and Pierre Le Pabic and Yashar Javidan and Tailin Zhang and Ken W. Y. Cho and J Gage Crump and Thomas F Schilling},
  journal={Development},
  year={2011},
  volume={138 23},
  pages={5135-46}
}
Bone morphogenetic proteins (BMPs) play crucial roles in craniofacial development but little is known about their interactions with other signals, such as Endothelin 1 (Edn1) and Jagged/Notch, which pattern the dorsal-ventral (DV) axis of the pharyngeal arches. Here, we use transgenic zebrafish to monitor and perturb BMP signaling during arch formation. With a BMP-responsive transgene, Tg(Bre:GFP), we show active BMP signaling in neural crest (NC)-derived skeletal precursors of the ventral… CONTINUE READING
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