Combinatorial protein design by in vitro recombination.

@article{Giver1998CombinatorialPD,
  title={Combinatorial protein design by in vitro recombination.},
  author={Lawrence P. Giver and Frances H. Arnold},
  journal={Current opinion in chemical biology},
  year={1998},
  volume={2 3},
  pages={
          335-8
        }
}
DNA recombination is a powerful engine for the creation of new phenotypes. Recently, methods for in vitro DNA recombination (DNA shuffling) have been developed and applied to the evolution of novel molecules in the laboratory. An exciting new development is the shuffling of homologous genes to create diversity for directed evolution. 

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