Combinatorial probabilistic chromatin interactions produce transcriptional heterogeneity.

@article{Voss2009CombinatorialPC,
  title={Combinatorial probabilistic chromatin interactions produce transcriptional heterogeneity.},
  author={Ty C. Voss and Richard L. Schiltz and Myong-Hee Sung and Thomas A. Johnson and Seffrin R. John and Gordon L. Hager},
  journal={Journal of cell science},
  year={2009},
  volume={122 Pt 3},
  pages={
          345-56
        }
}
Gene regulation often appears deterministic in the average cell population, but transcription is a probabilistic process at the single-cell level. Although many mechanisms are invoked to account for this behavior, it is difficult to determine how cell-to-cell variation in the interactions of transcription factors with target chromatin impact transcriptional output. Here, we use cells that contain a 200-copy tandem array of promoter or reporter gene units to simultaneously visualize transient… CONTINUE READING

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