Combinatorial optimization models for finding genetic signatures from gene expression datasets.

@article{Berretta2008CombinatorialOM,
  title={Combinatorial optimization models for finding genetic signatures from gene expression datasets.},
  author={Regina Berretta and Wagner Costa and Pablo Moscato},
  journal={Methods in molecular biology},
  year={2008},
  volume={453},
  pages={363-77}
}
The aim of this chapter is to present combinatorial optimization models and techniques for the analysis of microarray datasets. The chapter illustrates the application of a novel objective function that guides the search for high-quality solutions for sequential ordering of expression profiles. The approach is unsupervised and a metaheuristic method (a memetic algorithm) is used to provide high-quality solutions. For the problem of selecting discriminative groups of genes, we used a supervised… CONTINUE READING
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