Combinatorial nanocarrier based drug delivery approach for amalgamation of anti-tumor agents in bresat cancer cells: an improved nanomedicine strategies

@inproceedings{Murugan2016CombinatorialNB,
  title={Combinatorial nanocarrier based drug delivery approach for amalgamation of anti-tumor agents in bresat cancer cells: an improved nanomedicine strategies},
  author={Chandran Murugan and Kathirvel Rayappan and R Kiruba Thangam and Ramasamy Bhanumathi and K. Shanthi and Raju Vivek and Ramasamy Thirumurugan and A. Bhattacharyya and Srinivasan Sivasubramanian and Palani Gunasekaran and Soundarapandian Kannan},
  booktitle={Scientific reports},
  year={2016}
}
Combination therapy of multiple drugs through a single system is exhibiting high therapeutic effects. We investigate nanocarrier mediated inhibitory effects of topotecan (TPT) and quercetin (QT) on triple negative breast cancer (TNBC) (MDA-MB-231) and multi drug resistant (MDR) type breast cancer cells (MCF-7) with respect to cellular uptake efficiency and therapeutic mechanisms as in vitro and in vivo. The synthesized mesoporous silica nanoparticle (MSN) pores used for loading TPT; the outer… CONTINUE READING
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