Combinatorial microscopy for the study of protein-membrane interactions in supported lipid bilayers: Order parameter measurements by combined polarized TIRFM/AFM.

@article{Oreopoulos2009CombinatorialMF,
  title={Combinatorial microscopy for the study of protein-membrane interactions in supported lipid bilayers: Order parameter measurements by combined polarized TIRFM/AFM.},
  author={John Oreopoulos and Christopher M Yip},
  journal={Journal of structural biology},
  year={2009},
  volume={168 1},
  pages={21-36}
}
Understanding the mechanisms of peptide-induced membrane disorder is critical to the design of novel antimicrobial and cell-penetrating peptides. One means of quantifying local structure and order/disorder is through the orientational order parameter, typically obtained using various spectroscopic approaches. We report here on the use of an image-based… CONTINUE READING