Combinatorial microRNA target predictions

  title={Combinatorial microRNA target predictions},
  author={Azra Krek and D. Gr{\"u}n and M. Poy and R. Wolf and Lauren Rosenberg and E. Epstein and P. MacMenamin and Isabelle da Piedade and K. Gunsalus and M. Stoffel and N. Rajewsky},
  journal={Nature Genetics},
  • Azra Krek, D. Grün, +8 authors N. Rajewsky
  • Published 2005
  • Medicine, Biology
  • Nature Genetics
  • MicroRNAs are small noncoding RNAs that recognize and bind to partially complementary sites in the 3′ untranslated regions of target genes in animals and, by unknown mechanisms, regulate protein production of the target transcript. Different combinations of microRNAs are expressed in different cell types and may coordinately regulate cell-specific target genes. Here, we present PicTar, a computational method for identifying common targets of microRNAs. Statistical tests using genome-wide… CONTINUE READING

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