Combinatorial microRNA target predictions

@article{Krek2005CombinatorialMT,
  title={Combinatorial microRNA target predictions},
  author={Azra Krek and D. Gr{\"u}n and M. Poy and R. Wolf and Lauren Rosenberg and E. Epstein and P. MacMenamin and Isabelle da Piedade and K. Gunsalus and M. Stoffel and N. Rajewsky},
  journal={Nature Genetics},
  year={2005},
  volume={37},
  pages={495-500}
}
  • Azra Krek, D. Grün, +8 authors N. Rajewsky
  • Published 2005
  • Medicine, Biology
  • Nature Genetics
  • MicroRNAs are small noncoding RNAs that recognize and bind to partially complementary sites in the 3′ untranslated regions of target genes in animals and, by unknown mechanisms, regulate protein production of the target transcript. Different combinations of microRNAs are expressed in different cell types and may coordinately regulate cell-specific target genes. Here, we present PicTar, a computational method for identifying common targets of microRNAs. Statistical tests using genome-wide… CONTINUE READING

    Figures, Tables, and Topics from this paper.

    Most mammalian mRNAs are conserved targets of microRNAs.
    • 6,369
    • Highly Influenced
    • PDF
    MicroRNAs: Target Recognition and Regulatory Functions
    • 14,262
    • Highly Influenced
    • PDF
    MicroRNA targeting specificity in mammals: determinants beyond seed pairing.
    • 3,447
    • Highly Influenced
    • PDF
    Silencing of microRNAs in vivo with ‘antagomirs’
    • 3,554
    • PDF
    Predicting effective microRNA target sites in mammalian mRNAs
    • 2,713
    • Highly Influenced
    • PDF
    miRBase: integrating microRNA annotation and deep-sequencing data
    • 3,255
    • PDF
    Oncomirs — microRNAs with a role in cancer
    • 6,232
    • PDF
    MicroRNA gene expression deregulation in human breast cancer.
    • 3,748
    • PDF

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 32 REFERENCES