Combinatorial immunoglobulin light chain variability creates sufficient B cell diversity to mount protective antibody responses against pathogen infections.

@article{Senn2003CombinatorialIL,
  title={Combinatorial immunoglobulin light chain variability creates sufficient B cell diversity to mount protective antibody responses against pathogen infections.},
  author={Beatrice M. Senn and Constantino L{\'o}pez-Mac{\'i}as and Ulrich Kalinke and Alain Lamarre and Armando Isibasi and Rolf Martin Zinkernagel and Hans Hengartner},
  journal={European journal of immunology},
  year={2003},
  volume={33 4},
  pages={
          950-61
        }
}
To analyze how combinatorial light (L) chain diversity influences the B cell repertoire, we studied mice with a homozygous immunoglobulin-heavy-chain null mutation (mu MT), in which the B cell developmental block was overridden by the expression of a transgenic immunoglobulin mu heavy (H) chain derived from a vesicular stomatitis virus Indiana serotype (VSV-IND)-neutralizing Ab (T11 mu MT mice). The randomly integrated transgene could not undergo secondary rearrangements and was expressed in… CONTINUE READING