Combinatorial flexibility of cytokine function during human T helper cell differentiation.

Abstract

In an inflammatory microenvironment, multiple cytokines may act on the same target cell, creating the possibility for combinatorial interactions. How these may influence the system-level function of a given cytokine is unknown. Here we show that a single cytokine, interferon (IFN)-alpha, can generate multiple transcriptional signatures, including distinct… (More)
DOI: 10.1038/ncomms4987

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Cite this paper

@article{Touzot2014CombinatorialFO, title={Combinatorial flexibility of cytokine function during human T helper cell differentiation.}, author={Maxime Touzot and Maximilien Grandclaudon and Antonio Cappuccio and Takeshi Satoh and Carolina Mart{\'i}nez-Cingolani and Nicolas Servant and Nicolas Manel and Vassili Soumelis}, journal={Nature communications}, year={2014}, volume={5}, pages={3987} }