Combinatorial epigenetics, "junk DNA", and the evolution of complex organisms.

@article{Zuckerkandl2007CombinatorialE,
  title={Combinatorial epigenetics, "junk DNA", and the evolution of complex organisms.},
  author={Emile Zuckerkandl and Giacomo Cavalli},
  journal={Gene},
  year={2007},
  volume={390 1-2},
  pages={232-42}
}
At certain evolutionary junctures, two or more mutations participating in the build-up of a new complex function may be required to become available simultaneously in the same individuals. How could this happen in higher organisms whose populations are small compared to those of microbes, and in which chances of combined nearly simultaneous highly specific favorable mutations are correspondingly low? The question can in principle be answered for regulatory evolution, one of the basic processes… CONTINUE READING
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