Combinatorial effects of the phytoestrogen genistein and of estradiol in uterus and liver of female Wistar rats

@article{Diel2006CombinatorialEO,
  title={Combinatorial effects of the phytoestrogen genistein and of estradiol in uterus and liver of female Wistar rats},
  author={Patrick Diel and Thorsten Hertrampf and Jan Seibel and Ute Laudenbach-Leschowsky and Susanne Kolba and G{\"u}nter Vollmer},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2006},
  volume={102},
  pages={60-70}
}
Neonatal genistein exposure disrupts ovarian and uterine development in the mouse by inhibiting cellular proliferation
TLDR
Results showed that the subcutaneous injection of genistein to neonatal mice induced the formation of multi-oocyte follicles and delayed the primordial follicle assembly in the ovaries, and the use of isoflavone-rich diets in humans and livestock receive closer examination.
The rat prepubertal uterine myometrium and not the luminal epithelium is predominantly affected by a chronic dietary genistein exposure
TLDR
Although the impact of a continuous, prenatally initiated exposure to dietary isoflavones on the uterine physiology of juvenile rats is modest, the possible priming effects of this exposure for beneficial or adverse late-onset consequences in adults should not be neglected.
Effects of a glyphosate‐based herbicide on the uterus of adult ovariectomized rats
TLDR
Results indicate that, although the uterine weight was not affected, GBH modulates the expression of estrogen‐sensitive genes.
UTEROTROPHIC RESPONSES AND MODULATION OF UTERINE GENE EXPRESSION INDUCED BY COMBINATIONS OF GENISTEIN AND COUMESTROL IN OVARIECTOMIZED MICE
TLDR
Endpoint specific and dose-dependent estrogenic responses and differential expression pattern of ERs and down-regulation of PR suggests that the tested compounds may potentially modify sensitivity and physiology of estrogen target organ, which may therefore play significant role in the prevention of endometrial cancer.
Oestrogen receptor α and β mRNA expression in testis of ganders fed diets containing different levels of phytoestrogens *
TLDR
The greater ERβ mRNA expression in testis from ganders fed diets with higher phytoestrogens levels diets in July than from males fed both diets in March and May, and the increasing of this expression in control birds from July in comparison to animals from May were noted.
Genistein effects on stromal cells determines epithelial proliferation in endometrial co-cultures.
Preliminary investigation of the effects of long-term dietary intake of genistein and daidzein on hepatic histopathology and biochemistry in domestic cats (Felis catus)
TLDR
Dietary isoflavones, at the current dose and duration of exposure do not appear to modulate hepatic enzyme production or histological parameters.
In Vitro Comparison of Estrogenic Activities of Popular Women’s Health Botanicals
TLDR
While hops and 8-PN, have highly potent ERα effects, licorice and its compounds have partial effects for ERα and ERβ, suggesting that red clover may be a relatively safe menopausal remedy.
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