Combinatorial delivery of superparamagnetic iron oxide nanoparticles (γFe2O3) and doxorubicin using folate conjugated redox sensitive multiblock polymeric nanocarriers for enhancing the chemotherapeutic efficacy in cancer cells.

@article{Nehate2017CombinatorialDO,
  title={Combinatorial delivery of superparamagnetic iron oxide nanoparticles (γFe2O3) and doxorubicin using folate conjugated redox sensitive multiblock polymeric nanocarriers for enhancing the chemotherapeutic efficacy in cancer cells.},
  author={Chetan Nehate and M. R. Aji Alex and A. Kumar and V. Koul},
  journal={Materials science & engineering. C, Materials for biological applications},
  year={2017},
  volume={75},
  pages={
          1128-1143
        }
}
Redox sensitive, folate conjugated multiblock polymeric system of (-PLGA-PEG-PLGA-urethane-ss-) demonstrated self-assembly into stable nanoplatforms. The polymeric nanocarriers were encapsulated with doxorubicin and highly crystalline γFe2O3 superparamagnetic iron oxide nanoparticles (SPIONs), for co-delivery of the same to cancer cells, with average particle size of ~170nm and zeta potential of ~-33mV. Furthermore, the designed formulation was evaluated for protein adsorption, hemo… Expand
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