Combinatorial content of CCL3L and CCL4L gene copy numbers influence HIV-AIDS susceptibility in Ukrainian children.

@article{ShostakovichKoretskaya2009CombinatorialCO,
  title={Combinatorial content of CCL3L and CCL4L gene copy numbers influence HIV-AIDS susceptibility in Ukrainian children.},
  author={Ludmila Shostakovich-Koretskaya and Gabriel Catano and Zoya A Chykarenko and Weijing He and German G. Gornalusse and Srinivas Mummidi and Racquel Sanchez and Matthew J. Dolan and Sunil K. Ahuja and Robert A. Clark and Hemant Kulkarni and Sunil Kumar Ahuja},
  journal={AIDS},
  year={2009},
  volume={23 6},
  pages={
          679-88
        }
}
OBJECTIVE CCL3L and CCL4L genes encode HIV-suppressive chemokines, colocalize on chromosome 17q12 and have copy number variation. Copy number variation of CCL3L associates with HIV-AIDS susceptibility. Here, we determined the influence of the combinatorial content of distinct CCL3L and CCL4L genes on HIV-AIDS susceptibility. METHODS By designing gene-specific assays, the association between doses of all CCL3L or CCL4L genes or their individual duplicated components (CCL3La/b and CCL4La/b… CONTINUE READING
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