Combinatorial chemoprevention of intestinal neoplasia

@article{Torrance2000CombinatorialCO,
  title={Combinatorial chemoprevention of intestinal neoplasia},
  author={Christopher J. Torrance and Peta E. Jackson and Elizabeth H. Montgomery and Kenneth W. Kinzler and Bert Vogelstein and Allan Wissner and Maria Nunes and Yuti Chernajovsky and Carolyn M. Discafani},
  journal={Nature Medicine},
  year={2000},
  volume={6},
  pages={1024-1028}
}
A combination of two drugs afforded remarkable protection from intestinal neoplasia in APCMin/+ mice, a murine model of human familial adenomatous polyposis (FAP). One of the drugs was sulindac, a prototypical non-steroidal anti-inflammatory drug with established chemopreventative activity. The second drug was EKI-569, a newly developed, irreversible inhibitor of the epidermal growth factor receptor kinase. Although 100% of the untreated APCMin/+ mice developed ∼20 polyps, nearly half the mice… CONTINUE READING
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