Combinatorial biosynthesis of polyketides--a perspective.

  title={Combinatorial biosynthesis of polyketides--a perspective.},
  author={Fong T Wong and Chaitan Khosla},
  journal={Current opinion in chemical biology},
  volume={16 1-2},
Since their discovery, polyketide synthases have been attractive targets of biosynthetic engineering to make 'unnatural' natural products. Although combinatorial biosynthesis has made encouraging advances over the past two decades, the field remains in its infancy. In this enzyme-centric perspective, we discuss the scientific and technological challenges that could accelerate the adoption of combinatorial biosynthesis as a method of choice for the preparation of encoded libraries of bioactive… CONTINUE READING

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