Combinatorial biosynthesis of lipopeptide antibiotics in Streptomyces roseosporus

@article{Baltz2005CombinatorialBO,
  title={Combinatorial biosynthesis of lipopeptide antibiotics in Streptomyces roseosporus},
  author={Richard H. Baltz and P. Dilkes Brian and Vivian P. W. Miao and Stephen K. Wrigley},
  journal={Journal of Industrial Microbiology and Biotechnology},
  year={2005},
  volume={33},
  pages={66-74}
}
Daptomycin is a cyclic lipopeptide antibiotic produced by Streptomyces roseosporus. Cubicin® (daptomycin-for-injection) was approved in 2003 by the FDA to treat skin and skin structure infections caused by Gram-positive pathogens. Daptomycin is particularly significant in that it represents the first new natural product antibacterial structural class approved for clinical use in three decades. The daptomycin gene cluster contains three very large genes (dptA, dptBC, and dptD) that encode the… 
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Daptomycin is a lipopeptide antibiotic produced by Streptomyces roseosporus and recently commercialized as Cubicin (daptomycin-for-injection) for treatment of skin and skin-structure infections
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Daptomycin is a lipopeptide antibiotic used clinically to treat infections caused by Gram-positive bacteria. Laboratory studies have shown that Staphylococcus aureus resistance to daptomycin occurs
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The structural properties of daptomycin, its biosynthesis, recent efforts for the generation of structural diversity, and its proposed mode of action are discussed.
NMR structural studies of the antibiotic lipopeptide daptomycin in DHPC micelles.
TLDR
To understand how daptomycin goes on to perturb bacterial membranes, its three-dimensional structure has been determined in the presence of 1,2-dihexanoyl-sn-glycero-3-phosphocholine (DHPC) micelles and the implications for the membrane perturbation mechanism are discussed.
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TLDR
This review examines the most recent literature evidences on daptomycin molecular structure, mechanism of action, bacterial spectrum, clinical uses, local delivery, toxicity and resistance.
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