Combinatorial active‐site variants confer sustained clavulanate resistance in BlaC β‐lactamase from Mycobacterium tuberculosis

@article{Egesborg2015CombinatorialAV,
  title={Combinatorial active‐site variants confer sustained clavulanate resistance in BlaC $\beta$‐lactamase from Mycobacterium tuberculosis},
  author={Philippe Egesborg and H{\'e}l{\`e}ne Carlettini and Jordan P Volpato and Nicolas Doucet},
  journal={Protein Science},
  year={2015},
  volume={24}
}
Bacterial resistance to β‐lactam antibiotics is a global issue threatening the success of infectious disease treatments worldwide. Mycobacterium tuberculosis has been particularly resilient to β‐lactam treatment, primarily due to the chromosomally encoded BlaC β‐lactamase, a broad‐spectrum hydrolase that renders ineffective the vast majority of relevant β‐lactam compounds currently in use. Recent laboratory and clinical studies have nevertheless shown that specific β‐lactam–BlaC inhibitor… 
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