Combinatorial Signaling in the Specification of Unique Cell Fates

  title={Combinatorial Signaling in the Specification of Unique Cell Fates},
  author={Gail V Flores and Hong Yang Duan and Huajun Yan and Raghavendra Nagaraj and Weimin Fu and Y C Zou and Markus Noll and Utpal Banerjee},
How multifunctional signals combine to specify unique cell fates during pattern formation is not well understood. Here, we demonstrate that together with the transcription factor Lozenge, the nuclear effectors of the EGFR and Notch signaling pathways directly regulate D-Pax2 transcription in cone cells of the Drosophila eye disc. Moreover, the specificity of D-Pax2 expression can be altered upon genetic manipulation of these inputs. Thus, a relatively small number of temporally and spatially… CONTINUE READING
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