Combinatorial Receptor Codes for Odors

@article{Malnic1999CombinatorialRC,
  title={Combinatorial Receptor Codes for Odors},
  author={Bettina Malnic and Junzo Hirono and Takaaki Sato and Linda B. Buck},
  journal={Cell},
  year={1999},
  volume={96},
  pages={713-723}
}
The discriminatory capacity of the mammalian olfactory system is such that thousands of volatile chemicals are perceived as having distinct odors. Here we used a combination of calcium imaging and single-cell RT-PCR to identify odorant receptors (ORs) for odorants with related structures but varied odors. We found that one OR recognizes multiple odorants and that one odorant is recognized by multiple ORs, but that different odorants are recognized by different combinations of ORs. Thus, the… CONTINUE READING
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