Combinatorial Patterning of Chromatin Regulators Uncovered by Genome-wide Location Analysis in Human Cells

@article{Ram2011CombinatorialPO,
  title={Combinatorial Patterning of Chromatin Regulators Uncovered by Genome-wide Location Analysis in Human Cells},
  author={Oren Ram and Alon Goren and Ido Amit and Noam Shoresh and Nir Yosef and Jason Ernst and Manolis Kellis and Melissa Gymrek and Robbyn Issner and Michael Coyne and T. Durham and Xiaolan Zhang and Julie A Donaghey and Charles B. Epstein and Aviv Regev and Bradley E. Bernstein},
  journal={Cell},
  year={2011},
  volume={147},
  pages={1628-1639}
}
Hundreds of chromatin regulators (CRs) control chromatin structure and function by catalyzing and binding histone modifications, yet the rules governing these key processes remain obscure. Here, we present a systematic approach to infer CR function. We developed ChIP-string, a meso-scale assay that combines chromatin immunoprecipitation with a signature readout of 487 representative loci. We applied ChIP-string to screen 145 antibodies, thereby identifying effective reagents, which we used to… CONTINUE READING
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