Combinatorial Optimization of Cystine-Knot Peptides towards High-Affinity Inhibitors of Human Matriptase-1

@inproceedings{Glotzbach2013CombinatorialOO,
  title={Combinatorial Optimization of Cystine-Knot Peptides towards High-Affinity Inhibitors of Human Matriptase-1},
  author={Bernhard Glotzbach and Michael Reinwarth and Niklas Weber and Sebastian Fabritz and Michael Tomaszowski and Heiko Fittler and Andreas Christmann and Olga Avrutina and Harald Kolmar},
  booktitle={PloS one},
  year={2013}
}
Cystine-knot miniproteins define a class of bioactive molecules with several thousand natural members. Their eponymous motif comprises a rigid structured core formed by six disulfide-connected cysteine residues, which accounts for its exceptional stability towards thermic or proteolytic degradation. Since they display a remarkable sequence tolerance within their disulfide-connected loops, these molecules are considered promising frameworks for peptide-based pharmaceuticals. Natural open-chain… CONTINUE READING
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