Combinatorial Histone Readout by the Dual Plant Homeodomain (PHD) Fingers of Rco1 Mediates Rpd3S Chromatin Recruitment and the Maintenance of Transcriptional Fidelity*

@article{McDaniel2016CombinatorialHR,
  title={Combinatorial Histone Readout by the Dual Plant Homeodomain (PHD) Fingers of Rco1 Mediates Rpd3S Chromatin Recruitment and the Maintenance of Transcriptional Fidelity*},
  author={Stephen L. McDaniel and Jennifer E. Fligor and C. Ruan and Haochen Cui and Joseph B Bridgers and Julia V DiFiore and A. Guo and B. Li and B. Strahl},
  journal={The Journal of Biological Chemistry},
  year={2016},
  volume={291},
  pages={14796 - 14802}
}
  • Stephen L. McDaniel, Jennifer E. Fligor, +6 authors B. Strahl
  • Published 2016
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • The plant homeodomain (PHD) finger is found in many chromatin-associated proteins and functions to recruit effector proteins to chromatin through its ability to bind both methylated and unmethylated histone residues. Here, we show that the dual PHD fingers of Rco1, a member of the Rpd3S histone deacetylase complex recruited to transcribing genes, operate in a combinatorial manner in targeting the Rpd3S complex to histone H3 in chromatin. Although mutations in either the first or second PHD… CONTINUE READING
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