Combinatorial DNA damage pairing model based on X-ray-induced foci predicts the dose and LET dependence of cell death in human breast cells.

@article{Vadhavkar2014CombinatorialDD,
  title={Combinatorial DNA damage pairing model based on X-ray-induced foci predicts the dose and LET dependence of cell death in human breast cells.},
  author={Nikhil Vadhavkar and Christopher Pham and Walter Georgescu and Thomas Deschamps and A C Heuskin and Jonathan Tang and Sylvain V. Costes},
  journal={Radiation research},
  year={2014},
  volume={182 3},
  pages={273-81}
}
In contrast to the classic view of static DNA double-strand breaks (DSBs) being repaired at the site of damage, we hypothesize that DSBs move and merge with each other over large distances (μm). As X-ray dose increases, the probability of having DSB clusters increases as does the probability of misrepair and cell death. Experimental work characterizing the… CONTINUE READING