Combinatorial Coexpression of Neural and Immune Multigene Families in Mouse Vomeronasal Sensory Neurons

@article{Ishii2003CombinatorialCO,
  title={Combinatorial Coexpression of Neural and Immune Multigene Families in Mouse Vomeronasal Sensory Neurons},
  author={Tomohiro Ishii and Junji Hirota and Peter Mombaerts},
  journal={Current Biology},
  year={2003},
  volume={13},
  pages={394-400}
}
The vomeronasal organ (VNO) is a chemosensory organ specialized in the detection of pheromones in higher vertebrates. In mouse and rat, two gene superfamilies, V1r and V2r vomeronasal receptor genes, are expressed in sensory neurons whose cell bodies are located in, respectively, the apical and basal layers of the VNO epithelium. Here, we report that neurons of the basal layer express another multigene family, termed H2-Mv, representing nonclassical class I genes of the major histocompatibility… CONTINUE READING