Combinations of polyclonal or monoclonal antibodies to proteins of the outer membranes of the two infectious forms of vaccinia virus protect mice against a lethal respiratory challenge.

@article{Lustig2005CombinationsOP,
  title={Combinations of polyclonal or monoclonal antibodies to proteins of the outer membranes of the two infectious forms of vaccinia virus protect mice against a lethal respiratory challenge.},
  author={Shlomo Lustig and Christiana Nichols Fogg and J. Charles Whitbeck and Roselyn J Eisenberg and Gary H Cohen and Bernard Moss},
  journal={Journal of virology},
  year={2005},
  volume={79 21},
  pages={13454-62}
}
Previous studies demonstrated that antibodies to live vaccinia virus infection are needed for optimal protection against orthopoxvirus infection. The present report is the first to compare the protective abilities of individual and combinations of specific polyclonal and monoclonal antibodies that target proteins of the intracellular (IMV) and extracellular (EV) forms of vaccinia virus. The antibodies were directed to one IMV membrane protein, L1, and to two outer EV membrane proteins, A33 and… CONTINUE READING