Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypes.

@article{Jacques2010CombinationsOG,
  title={Combinations of genetic mutations in the adult neural stem cell compartment determine brain tumour phenotypes.},
  author={Thomas S Jacques and Alexander Swales and Monika Julianna Brzozowski and Nico V. Henriquez and Jacqueline M. Linehan and Zaman Mirzadeh and Catherine O' Malley and Heike Naumann and Arturo Alvarez-Buylla and Sebastian Brandner},
  journal={The EMBO journal},
  year={2010},
  volume={29 1},
  pages={
          222-35
        }
}
It has been suggested that intrinsic brain tumours originate from a neural stem/progenitor cell population in the subventricular zone of the post-natal brain. However, the influence of the initial genetic mutation on the phenotype as well as the contribution of mature astrocytes to the formation of brain tumours is still not understood. We deleted Rb/p53, Rb/p53/PTEN or PTEN/p53 in adult subventricular stem cells; in ectopically neurografted stem cells; in mature parenchymal astrocytes and in… CONTINUE READING
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